Select up to 3 choices to compare.
Select up to 2 choices to compare.
Daily oral PrEP with Truvada®
2+1+1 (on-demand oral PrEP) with Truvada®
Daily oral PrEP with Descovy®
Injectable PrEP with Cabotegravir
Injectable PrEP with Lenacapavir
A pill you take daily to prevent HIV.
Truvada® pills you take only before and then after sex to prevent HIV.
A pill you take daily to prevent HIV.
One injection you get in your butt muscle to prevent HIV.
Two injections you get under the skin on your belly, upper arm, thigh, or butt to prevent HIV.
1 pill, daily.
Take 2 pills from 2 to 24 hours before sex. Then 1 pill per day for 2 days after sex.
1 pill, daily.
Two injections one month apart, then every 2 months (8 weeks).
Every 6 months.
Less expensive than other PrEP.
Better for cholesterol & weight gain than Descovy®.
Fewer pills than daily PrEP if you can time your pill-taking with sex.
Less expensive.
Small pill.
Improved kidney function and bone density compared to Truvada®.
No tracking pills.
Sex anytime.
More private.
No tracking pills.
Sex anytime.
More private.
You should take it daily.
Large pill.
Less private than injectable.
Need to plan pills around sex.
Large pill size.
Less private than injectable.
You should take it daily.
Not yet tested for receptive vaginal/front hole sex or 2+1+1 PrEP.
Less private than injectable.
Requires clinic visits every 2 months.
Medication leaves the body slowly when you stop. You must switch to pills to maintain protection and avoid resistance to drugs in this class.
Requires clinic visit.
Medication leaves the body slowly when you stop. You must switch to pills to maintain protection.
Some people get headaches, abdominal pain, and/or nausea.
Kidney issues or bone density loss are rare but possible.
Some people get headaches and/or abdominal pain.
Kidney issues or bone density loss are rare but possible.
Some people get headaches, diarrhea, nausea, fatigue, and/or abdominal pain.
Can cause an increase in blood pressure or cholesterol.
It can hurt where you get the shot.
Some people get headaches, fever, and muscle aches.
Can have small increases in cholesterol, blood pressure, and/or weight.
It can hurt where you get the shot.
A lot of people get a nodule under the skin (¾ to 1 ½ inches) that lasts an average of 10 months.
Some people get headaches or nausea.
